Predictors identified for surgery and vision loss in chronic SJS

A multicenter retrospective cohort study analyzed 228 eyes from 115 patients with chronic Stevens-Johnson syndrome using machine-learning and regression models to identify predictors of ocular surgery and vision loss. The study reported that lid margin keratinization and conjunctivalization predicted need for surgery, while longer follow-up duration, systemic immunomodulatory therapy, and prior exposure to antibiotics or NSAIDs predicted progressive vision loss; median delay to presentation at specialized centers was one year and 53.5% of eyes underwent surgery. The authors state that delayed referral and limited acute-phase therapy use may contribute to poor outcomes.

Most relevant for: Patients with chronic Stevens-Johnson syndrome and clinicians managing their long-term ocular surface complications.

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