Single-cell study finds two distinct immune subtypes in Sjögren's disease

Using single-cell RNA sequencing and surface protein profiling on peripheral blood from 333 participants, researchers identified two immunological endotypes of Sjögren's disease based on anti-SSA antibody status. SSA-positive participants showed a persistent type I interferon signature and altered transitional B cell populations, including reduced BCR diversity and shorter CDR3 regions, while SSA-negative participants showed limited transcriptional differences from symptomatic non-SjD controls. The authors state these findings support a two-disease model of Sjögren's disease and identify transitional B cells as a potential biomarker and therapeutic target.

Most relevant for: Patients with Sjögren's disease, particularly those being evaluated by anti-SSA antibody status for potential disease subtyping or targeted treatment approaches.

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