LAIAs linked to fewer relapses than oral antipsychotics in bipolar disorder

A self-controlled case series using Hong Kong electronic health records compared long-acting injectable antipsychotics (LAIAs) with oral antipsychotics in 2,086 individuals with bipolar disorder who had received both. The study reported that LAIAs were associated with lower rates of emergency department visits, all-cause and psychiatric hospitalizations, and hospitalizations for manic or mixed episodes, with no significant difference for depressive episode hospitalizations or cardiovascular hospitalizations; LAIAs were also associated with an initially increased risk of extrapyramidal symptoms that was not significant beyond 90 days.

Most relevant for: Individuals with bipolar disorder being treated with antipsychotic medications, particularly during transitions between oral and long-acting injectable formulations.

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