Perioperative esketamine linked to less chronic pain after thoracoscopic surgery

A multicentre, randomised, double-blind trial of 873 patients compared perioperative low-dose esketamine infusion with saline in patients undergoing video-assisted thoracoscopic lung resection. The trial reported that esketamine reduced the incidence of chronic pain at 3 months (14.7% vs 21.2%), lowered early postoperative pain scores, and decreased supplemental analgesic use, without increasing adverse effects.

Most relevant for: Patients undergoing video-assisted thoracoscopic lung resection and perioperative teams managing their pain control.

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