No extended anticoagulation non-inferior after saphenous vein ablation

The TRAIN trial, a multicentre randomised controlled study, compared no extended thromboprophylaxis with 14 days of rivaroxaban 10 mg daily after radiofrequency ablation for incompetent saphenous veins in patients without prior DVT. The trial reported that omitting extended anticoagulation was non-inferior to rivaroxaban for thrombosis related events at 30 days, with one clinically relevant non-major bleeding event occurring in the rivaroxaban group and none in the no-anticoagulation group.

Most relevant for: Patients without prior deep vein thrombosis undergoing endovenous radiofrequency ablation for saphenous vein incompetence, with or without concomitant phlebectomy or sclerotherapy.

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