Recent glucocorticoid dosing linked to organ damage risk in SLE

A Swedish nationwide cohort study of 3,749 patients with newly diagnosed systemic lupus erythematosus examined how oral glucocorticoid dosing patterns over time relate to organ damage. The study found that organ damage risk was best captured by glucocorticoid exposure over the past one to two years (adjusted HR 1.34-1.42 per 5 mg/day), while cardiovascular damage risk required looking back three years. The authors concluded that glucocorticoid exposure over at least the previous year should be considered when evaluating overall organ damage, with a longer three-year window needed for cardiovascular damage.

Most relevant for: Patients with systemic lupus erythematosus on long-term oral glucocorticoid therapy, particularly regarding cardiovascular risk assessment.

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