Hypofractionated PMRT Noninferior to Conventional in Reconstruction Patients

This randomized trial (RT CHARM, Alliance A221505) compared 16-fraction hypofractionated postmastectomy radiation therapy with conventional 25-fraction PMRT in 898 women undergoing breast reconstruction. The trial reported 24-month reconstruction complication rates of 12.3% with hypofractionated versus 10.2% with conventional PMRT, meeting the prespecified noninferiority margin, with no statistically significant differences in locoregional recurrence or acute/late toxicity. The authors concluded that the hypofractionated regimen is safe and noninferior to conventional PMRT in this population.

Most relevant for: Women with invasive breast cancer undergoing mastectomy with immediate or delayed breast reconstruction requiring postmastectomy radiation therapy.

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