PGE2 signaling found to modulate MRGPRX2-mediated anaphylaxis severity

A study combining murine models, isolated mast cells, and anaphylaxis registry data examined how prostaglandin E2 (PGE2) regulates anaphylaxis triggered via the MRGPRX2/Mrgprb2 pathway. The researchers report that PGE2 attenuates MRGPRX2/b2-driven mast cell activation primarily through EP2, EP3, and EP4 receptor signaling, and that aspirin, which reduces PGE2, potentiated this anaphylaxis in mice. Registry data indicated that anaphylaxis severity from MRGPRX2-acting drugs was increased when NSAIDs were taken concomitantly; the authors state further studies are needed to determine whether EP receptors could serve as therapeutic targets.

Most relevant for: Patients experiencing drug-induced anaphylaxis via the MRGPRX2 pathway, particularly when NSAIDs or aspirin are co-administered.

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