New HA filler crosslinking method boosts projection without higher modification

This preclinical and physicochemical study evaluated a new hyaluronic acid (HA) filler, TPVM, made using an optimized crosslinking process (PNT+), comparing it with existing resilient HA (RHA) fillers. The study reports that despite having among the lowest degree of chemical modification among marketed fillers, TPVM achieved the highest elastic modulus and resistance to compression force, was rated easy to inject in over 94% of cases, degraded fully with hyaluronidase within 30 minutes, and showed smooth tissue integration without encapsulation or persistent inflammation in minipigs followed up to 156 weeks. The authors state this demonstrates that mechanical performance can be decoupled from degree of chemical modification while preserving enzymatic reversibility and tissue integration.

Most relevant for: Relevant to injectors considering hyaluronic acid filler selection for deep structural support indications such as midface, chin retrusion, and jawline augmentation.

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