UFE safety advantage over myomectomy varies by surgical subtype

A retrospective claims-based study of 59,484 women compared 30-day safety outcomes between uterine fibroid embolization (UFE) and myomectomy, analyzing myomectomy overall and stratified by abdominal, laparoscopic, and hysteroscopic subtype. The study reported that UFE had significantly lower rates of major adverse events, readmission, and bleeding than abdominal and (to a lesser extent) laparoscopic myomectomy, but higher rates of these outcomes than hysteroscopic myomectomy, with UFE also associated with higher ED visit rates than all myomectomy subtypes. The authors state that pooling myomectomy subtypes, as prior studies have often done, can obscure clinically meaningful safety differences relative to UFE.

Most relevant for: Women aged 25-50 considering uterus-preserving fibroid treatment options, including choice between embolization and myomectomy subtype.

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