MRI-guided PET reconstruction cuts false positives in amyloid imaging

A retrospective single-institution study compared MRI-guided versus OSEM reconstruction of florbetapir amyloid PET/MRI scans in 120 patients, with four blinded readers assessing amyloid status against a consensus reference standard. The study reported higher interreader agreement with MRI-guided reconstruction (Fleiss kappa 0.91 vs 0.79) and improved specificity (99.2% vs 91.6%), reducing false-positive amyloid classifications from 8.1% to 0.8%, while Centiloid-based separation between amyloid-negative and amyloid-positive groups was preserved with both methods.

Most relevant for: Patients undergoing amyloid PET/MRI evaluation, such as for diagnostic workup of suspected Alzheimer disease or other amyloid-related conditions.

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