Lymphovascular Invasion Linked to Worse Survival in Laryngeal Cancer

A national database analysis of 10,052 surgically treated laryngeal squamous cell carcinoma patients found that lymphovascular invasion (LVI), present in 20.3% of cases, was independently associated with worse overall survival (HR 1.22) after adjusting for demographics, comorbidity, stage, subsite, margins, facility type, and treatment. The association persisted in both glottic and supraglottic tumors and remained significant beyond 24 months of follow-up. Among patients with LVI, the study reported that postoperative radiotherapy and postoperative chemoradiotherapy were associated with improved survival compared with surgery alone.

Most relevant for: Patients with surgically treated laryngeal squamous cell carcinoma, particularly those found to have lymphovascular invasion on pathology.

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