Circadian-Feedback App Reduced Mood Episode Recurrence in Trial
A multicenter, double-blind, sham-controlled randomized trial tested a smartphone app (CRM) that delivers personalized circadian rhythm feedback using passive sensor data in 93 adults with major depressive disorder or bipolar disorder over 12 months. The trial reported that participants using the active app had significantly fewer recurrent mood episodes, fewer cumulative recurrence days, and longer time to recurrence than those using a sham app, with no significant adverse effects observed. The authors concluded the app has potential as a scalable digital chronotherapeutic adjunct to standard care.
Most relevant for: Adults with major depressive disorder or bipolar disorder being managed for recurrence prevention.
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