Prepectoral and subpectoral implant reconstruction show similar outcomes after radiotherapy

A multicenter randomized trial (FABREC) prospectively compared prepectoral (PP-IBR, n=224) and subpectoral (SP-IBR, n=156) implant-based breast reconstruction in patients receiving post-mastectomy radiotherapy, assessing complications, aesthetic results, and patient-reported outcomes at 6 and 18 months. The study reported no significant differences between the two techniques in FACT-B or BREAST-Q measures at either timepoint; SP-IBR was associated with lower aesthetic scores at 6 months, but this difference did not persist at 18 months. The authors reported that patient factors, particularly higher BMI (linked to lower sexual well-being) and older age, were more prominent predictors of outcomes than reconstruction technique itself.

Most relevant for: Patients undergoing implant-based breast reconstruction who require post-mastectomy radiotherapy.

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