Pleomorphic dermal sarcoma genetically resembles cutaneous SCC, not sarcoma

This retrospective cohort study from Dana-Farber and Brigham and Women's Hospital compared tumor genetic sequencing across 9 pleomorphic dermal sarcomas (PDS), 15 metastatic cutaneous squamous cell carcinomas (CSCC), and 25 soft-tissue sarcomas (STS). The study reported that PDS and CSCC had similar mean tumor mutational burden, shared UV signature mutations, and overlapping mutational clusters on principal component analysis, all of which were distinct from STS, which lacked major pathway mutations and UV signatures. The authors state these findings suggest PDS shares genetic profiling with metastatic CSCC rather than with soft-tissue sarcomas.

Most relevant for: Patients diagnosed with pleomorphic dermal sarcoma, a rare skin tumor for which management guidance has been unclear between sarcoma and cutaneous carcinoma treatment paradigms.

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