Central pain features, not inflammation, predict persistent pain in IA

This 2-year prospective study followed 66 patients with newly diagnosed inflammatory arthritis, tracking pain persistence using patient-reported outcomes, ultrasound, and quantitative sensory testing. The study reported that baseline and longitudinal inflammation was not associated with subsequent pain, whereas centrally mediated pain markers, fibromyalgia severity, painDETECT scores, and anxiety measures were the strongest predictors of persistent pain at 6, 12, and 24 months. The authors state that early identification and treatment of centrally mediated pain features may improve pain-related outcomes in this population.

Most relevant for: Patients with newly diagnosed inflammatory arthritis who report persistent pain despite controlled inflammation.

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