Case series links mushroom toxin to reversible acute kidney injury

A retrospective series from Yunnan, China described five patients who developed gastrointestinal symptoms 4-31 hours after ingesting mushrooms from a specific section, followed by oliguria and rapidly rising creatinine consistent with KDIGO stage 1-3 acute kidney injury. All patients received supportive care, four underwent continuous renal replacement therapy, and all recovered and were discharged after 11-27 days. The authors detected the nephrotoxin 2-amino-4,5-hexadienoic acid in all implicated mushroom specimens and state that recognizing this toxidrome may aid early differentiation from amatoxin poisoning and support timely initiation of renal replacement therapy.

Most relevant for: Clinicians managing suspected mushroom-related acute kidney injury, particularly in regions where this mushroom section is encountered.

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